BIBLIOGRAFÍA

1. Miravitlles M, Calle M, Molina J, Almagro P, Gomez JT, Trigueros JA, et al. Spanish COPD Guidelines (GesEPOC) 2021: Updated Pharmacological treatment of stable COPD. Arch Bronconeumol (Engl Ed). 2021.

2. Divo MJ, Celli BR, Poblador-Plou B, Calderon-Larranaga A, de-Torres JP, Gimeno-Feliu LA, et al. Chronic Obstructive Pulmonary Disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort. PLoS One. 2018;13:e0193143.

3. Gomez-Cabrero D, Menche J, Vargas C, Cano I, Maier D, Barabasi AL, et al. From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration. BMC Bioinformatics. 2016;17:441.

4. Sode BF, Dahl M, Nordestgaard BG. Myocardial infarction and other co-morbidities in patients with chronic obstructive pulmonary disease: a Danish nationwide study of 7.4 million individuals. Eur Heart J. 2011;32:2365-75.

5. Almagro P, Cabrera FJ, Diez-Manglano J, Boixeda R, Recio J, Mercade J, et al. Comorbidome and short-term prognosis in hospitalised COPD patients: the ESMI study. Eur Respir J. 2015;46:850-3.

6. Morgan AD, Rothnie KJ, Bhaskaran K, Smeeth L, Quint JK. Chronic obstructive pulmonary disease and the risk of 12 cardiovascular diseases: a population-based study using UK primary care data. Thorax. 2018;73:877-9.

7. Alter P, Mayerhofer BA, Kahnert K, Watz H, Waschki B, Andreas S, et al. Prevalence of cardiac comorbidities, and their underdetection and contribution to exertional symptoms in COPD: results from the COSYCONET cohort. Int J Chron Obstruct Pulmon Dis. 2019;14:2163-72.

8. Sinha SS, Gurm HS. The double jeopardy of chronic obstructive pulmonary disease and myocardial infarction. Open Heart. 2014;1:e000010.

9. Hoiseth AD, Neukamm A, Karlsson BD, Omland T, Brekke PH, Soyseth V. Elevated high-sensitivity cardiac troponin T is associated with increased mortality after acute exacerbation of chronic obstructive pulmonary disease. Thorax. 2011;66:775-81.

10. Frazao M, Silva PE, Frazao W, da Silva VZM, Correia MAV, Jr., Neto MG. Dynamic Hyperinflation Impairs Cardiac Performance During Exercise in COPD. J Cardiopulm Rehabil Prev. 2019;39:187-92.

11. Magnussen H, Canepa M, Zambito PE, Brusasco V, Meinertz T, Rosenkranz S. What can we learn from pulmonary function testing in heart failure? Eur J Heart Fail. 2017;19:1222-9.

12. Li C, Cheng W, Guo J, Guan W. Relationship of inhaled long-acting bronchodilators with cardiovascular outcomes among patients with stable COPD: a meta-analysis and systematic review of 43 randomized trials. Int J Chron Obstruct Pulmon Dis. 2019;14:799-808.

13. Zvizdic F, Begic E, Mujakovic A, Hodzic E, Prnjavorac B, Bedak O, et al. Beta-blocker Use in Moderate and Severe Chronic Obstructive Pulmonary Disease. Med Arch. 2019;73:72-5.

14. Sholter DE, Armstrong PW. Adverse effects of corticosteroids on the cardiovascular system. Can J Cardiol. 2000;16:505-11.

15. Shi Q, Zhang B, Xing H, Yang S, Xu J, Liu H. Patients with Chronic Obstructive Pulmonary Disease Suffer from Worse Periodontal Health-Evidence from a Meta-Analysis. Front Physiol. 2018;9:33.

16. Baldomero AK, Siddiqui M, Lo CY, Petersen A, Pragman AA, Connett JE, et al. The relationship between oral health and COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2019;14:881-92.

17. Zhou X, Wang Z, Song Y, Zhang J, Wang C. Periodontal health and quality of life in patients with chronic obstructive pulmonary disease. Respir Med. 2011;105:67-73.

18. Huang C, Liu Y, Shi G. A systematic review with meta-analysis of gastroesophageal reflux disease and exacerbations of chronic obstructive pulmonary disease. BMC Pulm Med. 2020;20:2.

19. Iliaz S, Iliaz R, Onur ST, Arici S, Akyuz U, Karaca C, et al. Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations? Respir Med. 2016;115:20-5.

20. Su VY, Liao HF, Perng DW, Chou YC, Hsu CC, Chou CL, et al. Proton pump inhibitors use is associated with a lower risk of acute exacerbation and mortality in patients with coexistent COPD and GERD. Int J Chron Obstruct Pulmon Dis. 2018;13:2907-15.

21. Xiong W, Zhang QS, Zhao W, Ding W, Liu JM, Zhao YF. A 12-month follow-up study on the preventive effect of oral lansoprazole on acute exacerbation of chronic obstructive pulmonary disease. Int J Exp Pathol. 2016;97:107-13.

22. Baumeler L, Papakonstantinou E, Milenkovic B, Lacoma A, Louis R, Aerts JG, et al. Therapy with proton-pump inhibitors for gastroesophageal reflux disease does not reduce the risk for severe exacerbations in COPD. Respirology. 2016;21:883-90.

23. Boeree MJ, Peters FT, Postma DS, Kleibeuker JH. No effects of high-dose omeprazole in patients with severe airway hyperresponsiveness and (a)symptomatic gastro-oesophageal reflux. Eur Respir J. 1998;11:1070-4.

24. Miyazaki H, Suda T, Otsuka A, Nagata M, Ozono S, Hashimoto D, et al. Tiotropium does not affect lower urinary tract functions in COPD patients with benign prostatic hyperplasia. Pulm Pharmacol Ther. 2008;21:879-83.

25. Afonso AS, Verhamme KM, Stricker BH, Sturkenboom MC, Brusselle GG. Inhaled anticholinergic drugs and risk of acute urinary retention. BJU Int. 2011;107:1265-72.

26. Kesten S, Jara M, Wentworth C, Lanes S. Pooled clinical trial analysis of tiotropium safety. Chest. 2006;130:1695-703.

27. Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543-54.

28. Singh S, Furberg CD. Inhaled anticholinergics for chronic obstructive pulmonary disease: comment on "Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease". Arch Intern Med. 2011;171:920-2.

29. Cole JM, Sheehan AH, Jordan JK. Concomitant use of ipratropium and tiotropium in chronic obstructive pulmonary disease. Ann Pharmacother. 2012;46:1717-21.

30. Stephenson A, Seitz D, Bell CM, Gruneir A, Gershon AS, Austin PC, et al. Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease: a population-based study. Arch Intern Med. 2011;171:914-20.

31. Loke YK, Singh S. Risk of acute urinary retention associated with inhaled anticholinergics in patients with chronic obstructive lung disease: systematic review. Ther Adv Drug Saf. 2013;4:19-26.

32. Bitar AN, Syed Sulaiman SA, Ali IAH, Khan I, Khan AH. Osteoporosis among Patients with Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-analysis of Prevalence, Severity, and Therapeutic Outcomes. J Pharm Bioallied Sci. 2019;11:310-20.

33. Munhoz da Rocha Lemos Costa T, Costa FM, Hoffman Jonasson T, Aguiar Moreira C, Boguszewski CL, Cunha Borges JL, et al. Bone mineral density and vertebral fractures and their relationship with pulmonary dysfunction in patients with chronic obstructive pulmonary disease. Osteoporos Int. 2018;29:2537-43.

34. Vestbo J, Anderson JA, Brook RD, Calverley PM, Celli BR, Crim C, et al. Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised controlled trial. Lancet. 2016;387:1817-26.

35. Caramori G, Ruggeri P, Arpinelli F, Salvi L, Girbino G. Long-term use of inhaled glucocorticoids in patients with stable chronic obstructive pulmonary disease and risk of bone fractures: a narrative review of the literature. Int J Chron Obstruct Pulmon Dis. 2019;14:1085-97.

36. Moon JY, Sin DD. Inhaled corticosteroids and fractures in chronic obstructive pulmonary disease: current understanding and recommendations. Curr Opin Pulm Med. 2019;25:165-72.

37. Jaitovich A, Barreiro E. Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. What We Know and Can Do for Our Patients. Am J Respir Crit Care Med. 2018;198:175-86.

38. Barreiro E, Gea J. Molecular and biological pathways of skeletal muscle dysfunction in chronic obstructive pulmonary disease. Chron Respir Dis. 2016;13:297-311.

39. Maltais F, Decramer M, Casaburi R, Barreiro E, Burelle Y, Debigare R, et al. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;189:e15-62.

40. Luo L, Zhao S, Wang J, Liu Y, Zhu Z, Xiang Q, et al. Association between chronic obstructive pulmonary disease and risk of erectile dysfunction: a systematic review and meta-analysis. Int J Impot Res. 2020;32:159-66.

41. Polland A, Davis M, Zeymo A, Venkatesan K. Comparison of Correlated Comorbidities in Male and Female Sexual Dysfunction: Findings From the Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). J Sex Med. 2018;15:678-86.

42. Barrecheguren M, Pinto L, Mostafavi-Pour-Manshadi SM, Tan WC, Li PZ, Aaron SD, et al. Identification and definition of asthma-COPD overlap: The CanCOLD study. Respirology. 2020;25:836-49.

43. Albertson TE, Chenoweth JA, Pearson SJ, Murin S. The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Expert Opin Pharmacother. 2020;21:213-31.

44. Plaza V, Alvarez F, Calle M, Casanova C, Cosio BG, Lopez-Vina A, et al. Consensus on the Asthma-COPD Overlap Syndrome (ACOS) Between the Spanish COPD Guidelines (GesEPOC) and the Spanish Guidelines on the Management of Asthma (GEMA). Arch Bronconeumol. 2017;53:443-9.

45. Martinez-Garcia MA, Maiz L, Olveira C, Giron RM, de la Rosa D, Blanco M, et al. Spanish Guidelines on the Evaluation and Diagnosis of Bronchiectasis in Adults. Arch Bronconeumol. 2018;54:79-87.

46. Martinez-Garcia MA, Maiz L, Olveira C, Giron RM, de la Rosa D, Blanco M, et al. Spanish Guidelines on Treatment of Bronchiectasis in Adults. Arch Bronconeumol (Engl Ed). 2018;54:88-98.

47. Kovacs G, Agusti A, Barbera JA, Celli B, Criner G, Humbert M, et al. Pulmonary Vascular Involvement in Chronic Obstructive Pulmonary Disease. Is There a Pulmonary Vascular Phenotype? Am J Respir Crit Care Med. 2018;198:1000-11.

48. Galie N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Respir J. 2015;46:903-75.

49. Gredic M, Blanco I, Kovacs G, Helyes Z, Ferdinandy P, Olschewski H, et al. Pulmonary hypertension in chronic obstructive pulmonary disease. Br J Pharmacol. 2021;178:132-51.

50. Mouronte-Roibas C, Fernandez-Villar A, Ruano-Ravina A, Ramos-Hernandez C, Tilve-Gomez A, Rodriguez-Fernandez P, et al. Influence of the type of emphysema in the relationship between COPD and lung cancer. Int J Chron Obstruct Pulmon Dis. 2018;13:3563-70.

51. Kauczor HU, Baird AM, Blum TG, Bonomo L, Bostantzoglou C, Burghuber O, et al. ESR/ERS statement paper on lung cancer screening. Eur Respir J. 2020;55.

52. Cejudo P, Lopez-Marquez I, Lopez-Campos JL, Marquez E, de la Vega F, Barrot E, et al. Exercise training in patients with chronic respiratory failure due to kyphoscoliosis: a randomized controlled trial. Respir Care. 2014;59:375-82.

53. Lee SH, Park JS, Kim SY, Kim DS, Kim YW, Chung MP, et al. Clinical features and prognosis of patients with idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Int J Tuberc Lung Dis. 2019;23:678-84.

54. Bergqvist J, Andersson A, Schioler L, Olin AC, Murgia N, Bove M, et al. Non-infectious rhinitis is more strongly associated with early-rather than late-onset of COPD: data from the European Community Respiratory Health Survey (ECRHS). Eur Arch Otorhinolaryngol. 2020;277:1353-9.

55. Hurst JR, Kuchai R, Michael P, Perera WR, Wilkinson TM, Wedzicha JA. Nasal symptoms, airway obstruction and disease severity in chronic obstructive pulmonary disease. Clin Physiol Funct Imaging. 2006;26:251-6.

56. Burkes RM, Ceppe AS, Doerschuk CM, Couper D, Hoffman EA, Comellas AP, et al. Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD: An Analysis of the SPIROMICS Cohort. Chest. 2020.

57. Alavi Foumani A, Mehrdad M, Jafarinezhad A, Nokani K, Jafari A. Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial. Int J Chron Obstruct Pulmon Dis. 2019;14:1495-501.

58. Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, et al. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019;74:337-45.

59. Xie F, Xie L. COPD and the risk of mild cognitive impairment and dementia: a cohort study based on the Chinese Longitudinal Health Longevity Survey. Int J Chron Obstruct Pulmon Dis. 2019;14:403-8.

60. Volotinen M, Hakkola J, Pelkonen O, Vapaatalo H, Maenpaa J. Metabolism of ophthalmic timolol: new aspects of an old drug. Basic Clin Pharmacol Toxicol. 2011;108:297-303.

61. Baudouin C, Labbe A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010;29:312-34.

62. Rosin LM, Bell NP. Preservative toxicity in glaucoma medication: clinical evaluation of benzalkonium chloride-free 0.5% timolol eye drops. Clin Ophthalmol. 2013;7:2131-5.

63. Ishii M, Horita N, Takeuchi M, Matsumoto H, Ebina-Shibuya R, Hara Y, et al. Inhaled Corticosteroid and Secondary Glaucoma: A Meta-analysis of 18 Studies. Allergy Asthma Immunol Res. 2021;13:435-49.

64. Zareifopoulos N, Bellou A, Spiropoulou A, Spiropoulos K. Prevalence, Contribution to Disease Burden and Management of Comorbid Depression and Anxiety in Chronic Obstructive Pulmonary Disease: A Narrative Review. COPD. 2019;16:406-17.

65. Divo M, Cote C, de Torres JP, Casanova C, Marin JM, Pinto-Plata V, et al. Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186:155-61.

66. Yohannes AM, Kaplan A, Hanania NA. Anxiety and Depression in Chronic Obstructive Pulmonary Disease: Recognition and Management. Cleve Clin J Med. 2018;85:S11-S8.

67. Arimura Y, Yamazaki S, Yanagi S, Matsumoto N, Takegami M, Hayashino Y, et al. Clinical usefulness of the two-question assessment tool for depressive symptoms in Japanese patients with chronic obstructive pulmonary disease. Lung. 2013;191:101-7.

68. Zewari S, Hadi L, van den Elshout F, Dekhuijzen R, Heijdra Y, Vos P. Obesity in COPD: Comorbidities with Practical Consequences? COPD. 2018;15:464-71.

69. Bianco A, Nigro E, Monaco ML, Matera MG, Scudiero O, Mazzarella G, et al. The burden of obesity in asthma and COPD: Role of adiponectin. Pulm Pharmacol Ther. 2017;43:20-5.

70. Littleton SW, Tulaimat A. The effects of obesity on lung volumes and oxygenation. Respir Med. 2017;124:15-20.

71. Goto T, Tsugawa Y, Faridi MK, Camargo CA, Jr., Hasegawa K. Reduced Risk of Acute Exacerbation of COPD After Bariatric Surgery: A Self-Controlled Case Series Study. Chest. 2018;153:611-7.

72. McDonald MN, Wouters EFM, Rutten E, Casaburi R, Rennard SI, Lomas DA, et al. It's more than low BMI: prevalence of cachexia and associated mortality in COPD. Respir Res. 2019;20:100.

73. Davalos-Yerovi V, Marco E, Sanchez-Rodriguez D, Guillen-Sola A, Duran X, Pascual EM, et al. Sarcopenia According to the Revised European Consensus on Definition and Diagnosis (EWGSOP2) Criteria Predicts Hospitalizations and Long-Term Mortality in Rehabilitation Patients With Stable Chronic Obstructive Pulmonary Disease. J Am Med Dir Assoc. 2019;20:1047-9.

74. Machado FVC, Schneider LP, Fonseca J, Belo LF, Bonomo C, Morita AA, et al. Clinical impact of body composition phenotypes in patients with COPD: a retrospective analysis. Eur J Clin Nutr. 2019;73:1512-9.

75. Putcha N, Fawzy A, Paul GG, Lambert AA, Psoter KJ, Sidhaye VK, et al. Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS. Ann Am Thorac Soc. 2018;15:710-7.

76. Kaptein AA, Fischer MJ, Scharloo M. Self-management in patients with COPD: theoretical context, content, outcomes, and integration into clinical care. Int J Chron Obstruct Pulmon Dis. 2014;9:907-17.

77. Tsiachristas A, Cramm JM, Nieboer A, Rutten-van Molken M. Broader economic evaluation of disease management programs using multi-criteria decision analysis. Int J Technol Assess Health Care. 2013;29:301-8.

78. Wagner EH, Austin BT, Von Korff M. Organizing care for patients with chronic illness. Milbank Q. 1996;74:511-44.

79. Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, et al. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 2006;173:1390-413.

80. Jonkman NH, Westland H, Trappenburg JC, Groenwold RH, Bischoff EW, Bourbeau J, et al. Do self-management interventions in COPD patients work and which patients benefit most? An individual patient data meta-analysis. Int J Chron Obstruct Pulmon Dis. 2016;11:2063-74.

81. Lenferink A, Brusse-Keizer M, van der Valk PD, Frith PA, Zwerink M, Monninkhof EM, et al. Self-management interventions including action plans for exacerbations versus usual care in patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017;8:CD011682.

82. Yadav UN, Lloyd J, Hosseinzadeh H, Baral KP, Harris MF. Do Chronic Obstructive Pulmonary Diseases (COPD) Self-Management Interventions Consider Health Literacy and Patient Activation? A Systematic Review. J Clin Med. 2020;9.

83. Rose L, Istanboulian L, Carriere L, Thomas A, Lee HB, Rezaie S, et al. Program of Integrated Care for Patients with Chronic Obstructive Pulmonary Disease and Multiple Comorbidities (PIC COPD(+)): a randomised controlled trial. Eur Respir J. 2018;51.

84. Kessler R, Casan-Clara P, Koehler D, Tognella S, Viejo JL, Dal Negro RW, et al. COMET: a multicomponent home-based disease-management programme versus routine care in severe COPD. Eur Respir J. 2018;51.

85. Jolly K, Sidhu MS, Bates E, Majothi S, Sitch A, Bayliss S, et al. Systematic review of the effectiveness of community-based self-management interventions among primary care COPD patients. NPJ Prim Care Respir Med. 2018;28:44.

86. Steurer-Stey C, Dalla Lana K, Braun J, Ter Riet G, Puhan MA. Effects of the "Living well with COPD" intervention in primary care: a comparative study. Eur Respir J. 2018;51.

87. Hernandez C, Alonso A, Garcia-Aymerich J, Serra I, Marti D, Rodriguez-Roisin R, et al. Effectiveness of community-based integrated care in frail COPD patients: a randomised controlled trial. NPJ Prim Care Respir Med. 2015;25:15022.

88. Hernandez C, Alonso A, Garcia-Aymerich J, Grimsmo A, Vontetsianos T, Garcia Cuyas F, et al. Integrated care services: lessons learned from the deployment of the NEXES project. Int J Integr Care. 2015;15:e006.

89. Lenferink A, van der Palen J, van der Valk P, Cafarella P, van Veen A, Quinn S, et al. Exacerbation action plans for patients with COPD and comorbidities: a randomised controlled trial. Eur Respir J. 2019;54.

90. Nici L, ZuWallack R, American Thoracic Society Subcommittee on Integrated Care of the CP. An official American Thoracic Society workshop report: the Integrated Care of The COPD Patient. Proc Am Thorac Soc. 2012;9:9-18.

91. Zwerink M, Brusse-Keizer M, van der Valk PD, Zielhuis GA, Monninkhof EM, van der Palen J, et al. Self management for patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014;3:CD002990.

92. Fabbri E, Zoli M, Gonzalez-Freire M, Salive ME, Studenski SA, Ferrucci L. Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research. J Am Med Dir Assoc. 2015;16:640-7.

93. Kruis AL, Smidt N, Assendelft WJ, Gussekloo J, Boland MR, Rutten-van Molken M, et al. Integrated disease management interventions for patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2013:CD009437.

94. Shaw G, Whelan ME, Armitage LC, Roberts N, Farmer AJ. Are COPD self-management mobile applications effective? A systematic review and meta-analysis. NPJ Prim Care Respir Med. 2020;30:11.

95. Curtis JR. Palliative and end-of-life care for patients with severe COPD. Eur Respir J. 2008;32:796-803.

96. Ecenarro PS, Iguiniz MI, Tejada SP, Malanda NM, Imizcoz MA, Marlasca LA, et al. Management of COPD in End-of-Life Care by Spanish Pulmonologists. COPD. 2018;15:171-6.

97. Gore JM, Brophy CJ, Greenstone MA. How well do we care for patients with end stage chronic obstructive pulmonary disease (COPD)? A comparison of palliative care and quality of life in COPD and lung cancer. Thorax. 2000;55:1000-6.

98. Au DH, Udris EM, Fihn SD, McDonell MB, Curtis JR. Differences in health care utilization at the end of life among patients with chronic obstructive pulmonary disease and patients with lung cancer. Arch Intern Med. 2006;166:326-31.

99. Pinnock H, Kendall M, Murray SA, Worth A, Levack P, Porter M, et al. Living and dying with severe chronic obstructive pulmonary disease: multi-perspective longitudinal qualitative study. BMJ Support Palliat Care. 2011;1:174-83.

100. Noseda A, Carpiaux JP, Markstein C, Meyvaert A, de Maertelaer V. Disabling dyspnoea in patients with advanced disease: lack of effect of nebulized morphine. Eur Respir J. 1997;10:1079-83.

101. Currow D, Louw S, McCloud P, Fazekas B, Plummer J, McDonald CF, et al. Regular, sustained-release morphine for chronic breathlessness: a multicentre, double-blind, randomised, placebo-controlled trial. Thorax. 2020;75:50-6.

102. Abernethy AP, Currow DC, Frith P, Fazekas BS, McHugh A, Bui C. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ. 2003;327:523-8.

103. Jensen D, Alsuhail A, Viola R, Dudgeon DJ, Webb KA, O'Donnell DE. Inhaled fentanyl citrate improves exercise endurance during high-intensity constant work rate cycle exercise in chronic obstructive pulmonary disease. J Pain Symptom Manage. 2012;43:706-19.

104. Johnson MA, Woodcock AA, Geddes DM. Dihydrocodeine for breathlessness in "pink puffers". Br Med J (Clin Res Ed). 1983;286:675-7.

105. Poole PJ, Veale AG, Black PN. The effect of sustained-release morphine on breathlessness and quality of life in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:1877-80.

106. Ekstrom MP, Bornefalk-Hermansson A, Abernethy AP, Currow DC. Safety of benzodiazepines and opioids in very severe respiratory disease: national prospective study. BMJ. 2014;348:g445.

107. Simon ST, Higginson IJ, Booth S, Harding R, Weingartner V, Bausewein C. Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev. 2016;10:CD007354.

108. Pisani L, Hill NS, Pacilli AMG, Polastri M, Nava S. Management of Dyspnea in the Terminally Ill. Chest. 2018;154:925-34.

109. Matsuo N, Morita T, Iwase S. Physician-reported corticosteroid therapy practices in certified palliative care units in Japan: a nationwide survey. J Palliat Med. 2012;15:1011-6; quiz 117-8.

110. Hardy JR, Rees E, Ling J, Burman R, Feuer D, Broadley K, et al. A prospective survey of the use of dexamethasone on a palliative care unit. Palliat Med. 2001;15:3-8.

111. Hui D, Kilgore K, Frisbee-Hume S, Park M, Tsao A, Delgado Guay M, et al. Dexamethasone for Dyspnea in Cancer Patients: A Pilot Double-Blind, Randomized, Controlled Trial. J Pain Symptom Manage. 2016;52:8-16 e1.

112. Dyspnea. Mechanisms, assessment, and management: a consensus statement. American Thoracic Society. Am J Respir Crit Care Med. 1999;159:321-40.

113. Schwartzstein RM, Lahive K, Pope A, Weinberger SE, Weiss JW. Cold facial stimulation reduces breathlessness induced in normal subjects. Am Rev Respir Dis. 1987;136:58-61.

114. Ekstrom M, Ahmadi Z, Bornefalk-Hermansson A, Abernethy A, Currow D. Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy. Cochrane Database Syst Rev. 2016;11:CD006429.

115. Abernethy AP, McDonald CF, Frith PA, Clark K, Herndon JE, 2nd, Marcello J, et al. Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet. 2010;376:784-93.

116. Campbell ML, Yarandi H, Dove-Medows E. Oxygen is nonbeneficial for most patients who are near death. J Pain Symptom Manage. 2013;45:517-23.

117. Pisani L, Fasano L, Corcione N, Comellini V, Musti MA, Brandao M, et al. Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD. Thorax. 2017;72:373-5.

118. Peters SG, Holets SR, Gay PC. High-flow nasal cannula therapy in do-not-intubate patients with hypoxemic respiratory distress. Respir Care. 2013;58:597-600.

119. Epstein AS, Hartridge-Lambert SK, Ramaker JS, Voigt LP, Portlock CS. Humidified high-flow nasal oxygen utilization in patients with cancer at Memorial Sloan-Kettering Cancer Center. J Palliat Med. 2011;14:835-9.

120. Cuomo A, Delmastro M, Ceriana P, Nava S, Conti G, Antonelli M, et al. Noninvasive mechanical ventilation as a palliative treatment of acute respiratory failure in patients with end-stage solid cancer. Palliat Med. 2004;18:602-10.

121. Almagro P, Yun S, Sangil A, Rodriguez-Carballeira M, Marine M, Landete P, et al. Palliative care and prognosis in COPD: a systematic review with a validation cohort. Int J Chron Obstruct Pulmon Dis. 2017;12:1721-9.

122. Carlucci A, Vitacca M, Malovini A, Pierucci P, Guerrieri A, Barbano L, et al. End-of-Life Discussion, Patient Understanding and Determinants of Preferences in Very Severe COPD Patients: A Multicentric Study. COPD. 2016;13:632-8.

123. Nava S, Sturani C, Hartl S, Magni G, Ciontu M, Corrado A, et al. End-of-life decision-making in respiratory intermediate care units: a European survey. Eur Respir J. 2007;30:156-64.